منابع مشابه
Pediatric antihypertensive trial failures: analysis of end points and dose range.
Historically, drugs prescribed for children have not been studied in pediatric populations. Since 1997, however, a 6-month extension of marketing rights is granted if manufacturers conduct Food and Drug Administration-defined pediatric trials. In nearly half of the drugs studied, there were unexpected results in dosing, safety, or efficacy compared with adult studies, including failure of half ...
متن کاملPediatric trials of antihypertensive agents: impact of trial design and unique pediatric factors on efficacy end points
2014 There is an increasing prevalence of pediatric hypertension worldwide due to the growing epidemic of childhood obesity. Recent regulatory changes in the USA and Europe have stimulated major pediatric clinical trials of 16 different antihypertensive agents, leading to US FDA labeling of 10 of these drugs. With increased pediatric hypertension trial experience, trial designs have been refine...
متن کاملSPEAR Trial: Smartphone Pediatric ElectrocARdiogram Trial
OBJECTIVES Smartphone-enabled ECG devices have the potential to improve patient care by enabling remote ECG assessment of patients with potential and diagnosed arrhythmias. This prospective study aimed to assess the usefulness of pediatric ECG tracings generated by the AliveCor device (Oklahoma City, OK) and to assess user satisfaction. STUDY DESIGN Enrolled pediatric patients with documented...
متن کاملA controlled trial of antihypertensive therapy in systemic sclerosis (scleroderma).
Antihypertensive treatment may be life saving in scleroderma renal crisis. Patients surviving such crises frequently have had dramatic improvement in the dermal manifestations of their scleroderma. To investigate the potential role of antihypertensive treatment in nonhypertensive patients we randomly assigned 28 patients with systemic sclerosis into drug (14) and placebo (14) groups, using bloc...
متن کامل[Candesartan Antihypertensive Survival Evaluation in Japan (CASE-J) trial].
Hypertension continues to be a major public health issue in the world. To combat this problem, many anti-hypertensive drugs have been developed and proven effective at controlling blood pressure in the last half century. In recent decades, antihypertensive drugs have been shown to have cardiovascular benefits beyond the reduction of blood pressure, and the focus has shifted to clarification of ...
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ژورنال
عنوان ژورنال: Hypertension
سال: 2008
ISSN: 0194-911X,1524-4563
DOI: 10.1161/hypertensionaha.107.108886